Release date: 2018-05-18
For many years, scientists have known that the gene EAK-7 plays an important role in determining the survival time of nematodes, but the researchers are not clear whether the gene has a similar version in the human body, if any, the gene is How does the human body function? Recently, a research report published in the international magazine Science Advances, researchers from the University of California first studied the mechanism of action of the gene called EAK-7 (mEAK-7) in the human body.
In the article, the researchers found that the mEAK-7 gene regulates a specific metabolic pathway that regulates cell growth and the development of the human body. The destruction of these processes is responsible for other diseases such as cancer and neurological disorders. First, in this study, the researchers hope to help develop new therapies by slowing down or blocking the molecular processes of the mEAK-7 gene, thereby controlling the cell growth and proliferation processes that cause disease.
In 2013, researchers began to study the EAK-7 gene in the nematode body. By elucidating the importance of this gene for nematodes, researchers wanted to understand whether the gene plays a key role in human organism biology, and they also I want to clarify why certain specific human cells are transformed into stem cells. Researcher Joe Nguyen said that we have unintentionally discovered that there is a certain correlation between the EAK-7 gene in the nematode and the same gene in humans. When the researchers identified the mEAK-7 gene in human cells, they screened various types of cells, hoping to better understand the working mechanism of the gene, including embryonic stem cells and fibroblasts (fiber-forming). Cells are able to form connective tissue and help promote wound healing).
The investigators said that we did not find the presence of mEAK-7 in any of the samples, but when we tested mEAK-7 in a variety of cancer cells, we found that the level of the mEAK-7 gene was very high; The cell undergoes a series of experiments to observe how mEAK-7 responds to the mTOR signal of the cell, which regulates the metabolism, growth, replication and survival of human cells. According to the researchers, the mEAK-7 gene actually activates other biological processes, the alternative pathway, which is not as easy to understand at the molecular level as mTOR.
Krebsbach said that with the discovery of the mEAK-7 gene activation pathway, we also found that cell metabolism, division and migration may depend on the type of cell, if we can find a way to control the replication of cells that induce disease. And migration, then we have the opportunity to develop new therapies for treating diseases. The researchers then examined the importance of the gene in cell proliferation and migration by inhibiting the mEAK-7 gene in human cells. When the gene is promoted or removed from the cell, the associated signaling process Significant decline, in addition, the researchers also tested whether the mEAK-7 gene is overexpressed in the cells, and found that with its overexpression, cell proliferation will be significantly accelerated.
Finally, the researcher Jin Koo Kim said that in this paper, we found that the mEAK-7 gene is very important for mTOR signaling in cells and is also required for cell proliferation and migration. By targeting the mEAK-7 gene, we can bypass Ways to intercept the mTOR signal to achieve effective control of disease progression.
Source: Bio Valley
Poultry Greenhouse,Poultry House For Breeding,Single Span Greenhouse,Single Span Poultry Greenhouse
Qingzhou JuLong Agriculture Equipment Co.,Ltd , https://www.julonggrowtech.com