It was learned from the University of Science and Technology of China that the Xiong Wei Research Group of the School of Life Science and the Huang Guangming Research Group of the School of Chemistry and Materials Science collaborated with the technical methods of single cell mass spectrometry, light genetics, molecular biology, electrophysiology and animal behavior. Reveals the mechanism of neural loops that improve learning, memory, and mood in the sun and a new pathway for glutamate synthesis in the brain. The relevant results were published online in the international academic journal Cell.
As we all know, moderate sunlight has many benefits for the human body, including the synthesis of vitamin D and the treatment of various skin diseases. In addition, people have also found that sunlight has a certain degree of influence on the nervous system. For example, moderate sunlight can improve people's emotions and cognition. However, due to the limitations of research methods, the deep mechanism underlying the changes in the behavior of the nervous system caused by sunlight exposure is currently unclear. How the sun shines on the skin finally affects the metabolism of nerve cells in the brain and the function of the neural circuits, has also been an unsolved mystery.
Xiong Wei and Huang Guangming's research team used their recently developed single-cell mass spectrometry technology, combined with various research methods of neuroscience, to discover that the sun exposure to the skin of animals caused a significant increase in the content of a chemical called UCA in the blood. Then they discovered that the increased UCA could enter the brain's nerve cells through the blood-brain barrier, where the UCA is ultimately converted to glutamate through a series of biometabolizing enzymes. The intracellular glutamate is released in the motor cortex and the nerve endings of the hippocampus, which in turn activates motor learning and memory-related intracerebral neural circuits, thereby enhancing the animal's motor learning ability and object recognition memory.
According to experts, this is the discovery of a new intracerebral glutamate biosynthetic pathway since the 1970s and 1980s. Since glutamate has many important physiological functions such as intracellular protein synthesis, energy metabolism, and excitatory nerve signal transmission in the brain, the discovery of this pathway will play a role in understanding the working mechanism of the brain and exploring the mechanisms of related diseases. Very important role. (Reporter Yan Wenya)
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