With the support of the 973 program, Chinese scientists have made major breakthroughs in the field of brain science. For the first time, the single-cell map of the development of the human prefrontal lobe is drawn and the important role of neural stem cells is revealed.
The human prefrontal cortex is a key component of the advanced function of the human brain, and participates in memory formation, short-term storage, and functions such as retrieval, language function, and mood regulation. The cellular composition of the prefrontal cortex is the biological basis for its formation of neural networks and for performing rich functions. However, the cells in the prefrontal cortex of the human brain are composed of cells, and how these cells are produced during embryonic development. These key scientific problems have been studied before.
Wang Xiaoqun, researcher and collaborator of the Institute of Biophysics, Chinese Academy of Sciences, used single-cell transcriptome sequencing to map a single-cell transcriptome of human prefrontal embryonic development, and analyzed the cell type diversity of human embryonic prefrontal development. And the developmental relationship between different cell types, revealing the molecular regulation mechanism of neural stem cell-based neuron production and loop formation, and systematically study the key cell types in order to draw the final intact human brain cells. The map has laid an important foundation. This study provides a high-precision cell map for answering the question of how the prefrontal cortex participates in the key issue of "thinking and thought formation" and is an important breakthrough in the research of prefrontal cortex development. Related results were recently published in the journal Nature. (Technology Department)
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