The visual-optical team led by Professor Zhou Xingtao of the Eye and Otolaryngology Hospital of Fudan University, after eight years of clinical practice and scientific research, has independently developed new therapies in the world, and used the previously abandoned corneal tissue lenses in femtosecond laser nearsightedness and farsightedness surgery. Treatment of patients with cone and corneal malnutrition makes it possible to see the light again. This achievement paper has been published in the latest edition of the international refractive surgery authoritative journal "Journal of refractive surgery" and has attracted the attention of domestic and foreign counterparts.
According to Zhou Xingtao, in the field of ophthalmology, keratoconus and corneal dystrophy are persistent. The keratoconus is characterized by corneal dilatation, deformation, central thinning and conical forward convexity. It often leads to irregular astigmatism and high myopia. In severe cases, it leads to blindness and requires corneal transplantation. Corneal dystrophy is a type of inheritance. Sexual primary progressive corneal disease requires corneal grafting at the end of its development and recurrence after transplantation. Due to the severe scarcity of corneal material, there is almost no eye bank that can provide enough corneal material for clinical use in China.
It is reported that the myopia removed by correcting nearsightedness is a myopic lens. The hyperopic lens is corrected for farsightedness. The hyperopic lens has the effect of reducing the myopia, and the myopia lens has the effect of reducing the hyperopia. These taken-out lenses are useless to the patient, and it is common practice at home and abroad to discard the removed lenses. Can these lenses be reused? It has always been a question for Zhou Xingtao's team to think about.
They observed the lenses taken out of myopic SMILE and farsighted SMILE under the electron microscope and found that the removed lenses were very complete and the surface was very smooth, suggesting that if used for transplantation, the optical quality would be very good. Since 2010, they have tried on animals such as rabbits and monkeys. The results suggest that the implanted lens not only has good biocompatibility, but also has a certain refractive power (ie, the implanted lens can generate degrees). Later, the team tried to apply this technology to the human eye and carried out research on the correction of hyperopia with self-implantation of myopia lenses. The results show that the operation is safe and effective, and the prediction formula (ie, the relationship between the degree of implantation of the lens and the degree of actual production) is obtained.
In 2015, under the guidance of Professor Zhou Xingtao, Dr. Li Meiyan originally implanted a hyperopia lens in the corneal layer of a keratoconus patient who is suffering from a corneal transplant. After two years of follow-up, the patient’s uncorrected visual acuity improved from 0.1 preoperatively. After surgery, the corrected visual acuity of the spectacles increased from 0.3 preoperatively to 0.5 postoperatively, myopia decreased from 1350 preoperatively to 325 degrees postoperatively, and astigmatism decreased from 600 degrees preoperatively to 150 degrees. This is the first time in the world that a fresh hyperopic lens has been successfully treated for the treatment of keratoconus; this technique also improves the refractive power (vision) while also thickening the cornea, avoiding corneal transplantation, and potentially strengthening the cornea and improving corneal biomechanics. Good effect.
Experts said that surface mirror technology has the potential to postpone corneal transplantation in patients with corneal dystrophy, reduce surgical trauma, and reduce the economic burden on patients. As a shallow surface graft material, the lens can reduce rejection and potentially increase biomechanical stability of the cornea, but its long-term stability still needs to be verified. (Reporter Sun Guogen correspondent Shen Aiqin)
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