Release date: 2018-05-15
Photodynamic therapy, with its small trauma and simple operation, is becoming an important means of cancer treatment. The treatment method needs to input the photosensitizer into the human body, and after a certain time, the lesion is irradiated with light of a specific wavelength, so that the abnormally proliferating and active cells undergo irreversible damage, and finally the cells are killed to achieve therapeutic purposes. Traditional photosensitizers are phototoxic to normal tissues, making them extremely limited in clinical applications. How to improve existing commercial photosensitizers is a very challenging problem. In recent years, "activatable" photosensitizers have been the focus of researchers for photodynamic therapy.
Recently, Guo Dongsheng team of the School of Chemistry of Nankai University and Ding Dan team of the College of Life Sciences jointly researched and developed the “activatable†nano-drugs, which overcomes the lack of tumor targeting, phototoxicity to normal tissues, and reduces the light. It is toxic and improves the therapeutic effect, and can realize the integration of diagnosis and treatment. This strategy has been successfully applied to live animal experiments, providing new methods for the clinical precision treatment of diseases such as tumors.
In order to achieve tumor selective imaging and targeted therapy, Guo Dongsheng's research group proposed a new strategy of “biomarker replacement activationâ€. Starting from the mature commercial photosensitizer, the amphiphilic calixarene is combined with a photosensitizer to construct a nano supramolecular drug through the interaction between the host and the guest, including the encapsulated photosensitizer by the calixarene "pocket".
After the strategy was verified by chemical theory, Ding Dan's research group successfully applied it to the imaging and treatment of living tumors. Ding Dan said: "When the photosensitizer is encapsulated in the body cavity, it is in a 'quiet' state; when the nano drug is transported to the tumor tissue area, the photosensitizer is displaced out of the cavity and reactivates its original light. Physical properties to achieve tumor-selective imaging and targeted therapy."
Guo Dongsheng and Ding Dan's research group proposed a novel strategy based on the subject-object chemistry concept, which realized tumor selective imaging and targeted therapy, and successfully applied in living anti-tumor. This pioneering work provides new ways to achieve precision medicine and develops new materials. (Correspondent Ma Chao)
Chinese Journal of Science and Technology (2018-05-15 8th Edition, Science and Technology)
Source: Chinese Journal of Science
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